Infectious Diseases Watch with Dr. Ed

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Infectious Diseases Watch with Dr. Ed

Edward J. Septimus, M.D., F.I.D.S.A, F.A.C.P, F.S.H.E.A.

Dr. Ed Septimus received his medical degree from Baylor College of Medicine in Houston in 1972. Dr. Septimus went on to complete his postgraduate training in internal medicine and infectious diseases at Baylor College of Medicine in Houston. Dr. Ed Septimus is board certified in both internal medicine and infectious diseases. He was VP Research and…

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Doxycycline vs. Cephalexin Treatment of Presumed Streptococcal Skin and Soft Tissue Infection Among Adults Presenting to the Emergency Department; Comparative Effectiveness of First-Line and Alternative Antibiotic Regimens in Hospitalized Patients with Nonsevere Community-Acquired Pneumonia; Incidence and Risk Factors for Subsequent Infections Among Rectal Carriers with Carbapenem-Resistant Klebsiella pneumoniae; Prevalence, Regional Distribution, and Trends of Antimicrobial Resistance Among Female Outpatients with Urine Klebsiella spp. Isolates; Effectiveness of Prophylactic Oral and/or Vaginal Probiotic Supplementation in the Prevention of Recurrent Urinary Tract Infections: RCT; Cefepime–Taniborbactam in Complicated Urinary Tract Infection; Oral Gepotidacin vs. Nitrofurantoin in Patients with Uncomplicated Urinary Tract Infection (EAGLE-2 and EAGLE-3); Oral β-Lactams, Fluoroquinolones, or Trimethoprim-Sulfamethoxazole for Definitive Treatment of Uncomplicated UTI due to E coli or Klebsiella Species Bacteremia; Impact of a Deep Learning Sepsis Prediction Model on Quality of Care and Survival; Artificial Intelligence for Early Sepsis Detection A Word of Caution; Development and Validation of the Phoenix Criteria for Pediatric Sepsis and Septic Shock; Job Flows Into and Out of Health Care Before and After the COVID-19 Pandemic; State-of-the-Art Review: Use of Antimicrobials at the End of Life; Selection of Antibiotics as Prophylaxis for Close Contacts of Patients with Meningococcal Disease in Areas with Ciprofloxacin Resistance; Characteristics and Prognosis Factors of Pneumocystis jirovecii Pneumonia According to Underlying Disease; Using Insurance Claims Data to Estimate Blastomycosis Incidence; Impact of Blood Culture Contamination (BCC) on Antibiotic Use, Resource Utilization, and Clinical Outcomes; External Validation of the 2023 Duke - International Society for Cardiovascular Infectious Diseases Diagnostic Criteria for Infective Endocarditis; Discontinuation of Contact Precautions (CP) for Methicillin-Resistant Staphylococcus aureus in a Pediatric Healthcare System; Safety and Efficacy of Midline vs Peripherally Inserted Central Catheters Among Adults Receiving IV Therapy; Maternal Vaccine Effectiveness Against Influenza-Associated Hospitalizations and Emergency Department Visits in Infants; Effect of Daily Vitamin D Supplementation on Risk of Upper Respiratory Infection in Older Adults; Short Oral Antibiotic Therapy for Pediatric Febrile Urinary Tract Infections; Skin Antisepsis before Surgical Fixation of Extremity Fractures; Aqueous Skin Antisepsis Before Surgical Fixation of Open Fractures (Aqueous-PREP); Topical Antibiotic Prophylaxis for Preventing Surgical Site Infections of Clean Wounds; Nasal Sanitizer (Nozin) under FDA Scrutiny; Randomized, Double-Blind, Phase 3 Safety and Efficacy Study of Ridinilazole vs. Vancomycin for Treatment of Clostridioides difficile Infection; AGA Clinical Practice Guideline on Fecal Microbiota–Based Therapies for Select Gastrointestinal Diseases; Effectiveness of High-Dose vs. Standard-Dose Quadrivalent Influenza Vaccine Against Recurrent Hospitalizations and MortalityiIn Relation to Influenza; Fatal Alaskapox Infection in a Southcentral Alaska Resident; Early Estimates of Updated 2023–2024 (Monovalent XBB.1.5) COVID-19 Vaccine Effectiveness Against Symptomatic SARS-CoV-2 Infection; CDC May Recommend Covid-19 Boosters for Some This Spring; Covid-19 by the Numbers; CDC Plans to Drop Five-Day Covid-19 Isolation Guidelines

March 2024

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The Utility of Risk Factors to Define Complicated Staphylococcus aureus bacteremia (SAB) in a Setting with Low MRSA Prevalence; Efficacy and Safety of an Early Oral Switch in Low-Risk Staphylococcus aureus Bloodstream Infection (SABATO); Global Incidence and Mortality of Severe Fungal Disease; Rapid Environmental Contamination with C auris and Multidrug-Resistant Bacterial Pathogens Near Colonized Patients; Efficacy and Safety of Rezafungin and Caspofungin in Candidaemia and Invasive Candidiasis; Sink-traps are a Major Source for Carbapenemase Producing Enterobacteriaceae Transmission; Do We Need to Administer Fludrocortisone in Addition to Hydrocortisone in Adult Patients with Septic Shock?; Transition to Oral Antibiotic Therapy for Hospitalized Adults with Gram-Negative Bloodstream Infections; Early Switch from Intravenous to Oral Antibiotics for Patients With Uncomplicated Gram-Negative Bacteremia; Oral Antibiotics for Treatment of Gram-Negative Bacteremia in Solid Organ Transplant Recipients; Prosthetic Joint Infections: 6 Weeks of Oral Antibiotics Results in a Low Failure Rate; Efficacy and Safety of a Structured De-Escalation from Antipseudomonal Β-Lactams in Bloodstream Infections Due to Enterobacterales; Fluoroquinolone Antibiotics: Prescribe Only as Last Resort; Mortality, Hospital Length of Stay, and Recurrent Bloodstream Infections Associated with ESBL-Producing Escherichia coli; Coverage Gaps in Empiric Antibiotic Regimens Used to Treat Serious Bacterial Infections in Neonates and Children in SE Asia and the Pacific; A Novel Antibiotic Class Targeting the Lipopolysaccharide Transporter; Taurolidine/Heparin Lock Solution and Catheter-Related Bloodstream Infection in Hemodialysis; Second Nationwide Tuberculosis Outbreak Caused by Bone Allografts Containing Live Cells; Recommended Adult Immunization Schedule; CDC Alerts Healthcare Providers About Measles Cases; Effectiveness of Recombinant Zoster Vaccine (RZV) Against Herpes Zoster in a Real-World Setting; Early Tecovirimat Treatment for Mpox Disease Among People with HIV; Detecting Mpox Cases Through Wastewater Surveillance; Norovirus GII Wastewater Monitoring for Epidemiological Surveillance; Clinical Impact of Multiplex Molecular Diagnostic Testing in Children with Acute Gastroenteritis Presenting to an Emergency Department; Burden of Medically-Attended Diarrhea and Outpatient C diff Infection Among Persons in Two Large Integrated Healthcare Settings; Effectiveness of Fidaxomicin vs Vancomycin in Populations with Immunocompromising Conditions for the Treatment of C diff Infection; The Combined Effect of Systemic Antibiotics and Proton Pump Inhibitors on Clostridioides difficile Infection and Recurrence; Respiratory Viruses by the Numbers; Virological Characteristics of the SARS-CoV-2 JN.1 Variant; Symptoms, Viral Loads, and Rebound Among COVID-19) Outpatients Treated with Nirmatrelvir/Ritonavir(N/R); The Effectiveness of COVID-19 Vaccines to Prevent Long COVID Symptoms; Hybrid Immunity to SARS-CoV-2 During Pregnancy; Oral Simnotrelvir for Adult Patients with Mild-to-Moderate Covid-19; SARS-CoV-2 Vaccination and Neuroimmunological Disease

February 2024

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An Open-Label, Randomized Trial Comparing Fidaxomicin with Oral Vancomycin for the Treatment of Clostridioides difficile Infection in Hospitalized Patients Receiving Concomitant Antibiotics for Concurrent Infections; Longitudinal Genomic Surveillance of Carriage and Transmission of Clostridioides difficile in an Intensive Care Unit; The Role of the Hospital Bed in Hospital-Onset Clostridioides difficile; Clade I–Associated Mpox Cases Associated with Sexual Contact, the Democratic Republic of the Congo; Multi-Country Outbreak of Mpox; Transmission of Mpox to Nonsexual Close Contacts; State-of-the-Art Review: Persistent Enterococcal Bacteremia; Conventional vs Short Duration of Antibiotics in Patients with Moderate or Severe Cholangitis; Maternal Vaccine Effectiveness Against Influenza-Associated Hospitalizations and Emergency Department Visits in Infants; Clinical Practice Guideline by the Pediatric Infectious Diseases Society (PIDS) and the Infectious Diseases Society of America (IDSA): 2023 Guideline on Diagnosis and Management of Acute Bacterial Arthritis in Pediatrics; Multicenter Evaluation of the BIOFIRE Joint Infection Panel for the Detection of Bacteria, Yeast, and AMR Genes in Synovial Fluid Samples; Postoperative Staphylococcus aureus Infections in Patients With and Without Preoperative Colonization; Assessing the Impact of Discordant Antibiotic Treatment on Adverse Outcomes in Community-Onset UTI; 2022 National and State Healthcare-Associated Infections Progress Report; Treatment Effectiveness of Antibiotic Therapy in Veterans with Multidrug-Resistant Acinetobacter spp. Bacteremia; Association Between Daily Toothbrushing and Hospital-Acquired Pneumonia A Systematic Review and Meta-Analysis; Doxycycline Prophylaxis to Prevent Sexually Transmitted Infections in Women; Respiratory Viruses in Wastewater Compared with Clinical Samples, Leuven, Belgium; Respiratory Viruses by the Number; Influenza, Updated COVID-19, and Respiratory Syncytial Virus Vaccination Coverage Among Adults; Outcomes of Pediatric SARS-CoV-2 Omicron Infection vs Influenza and Respiratory Syncytial Virus Infections; COVID-19 Rapid Antigen Tests with Self-Collected vs Health Care Worker–Collected Nasal and Throat Swab Specimens; A Synbiotic Preparation (SIM01) for Post-Acute COVID-19 Syndrome in Hong Kong (RECOVERY); Viral Dynamics of the SARS-CoV-2 Omicron Variant in Pediatric Patients: A Prospective Cohort Study; Developmental Impairment in Children Exposed During Pregnancy to Maternal SARS-CoV2; WHO Designates JN.1 as Separate COVID-19 variant of Interest; Digital Measurement of SARS-CoV-2 Transmission Risk from 7.2 Million Contacts; SARS-CoV-2 Rebound With and Without Use of COVID-19 Oral Antivirals

January 2024

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Procalcitonin Monitoring and Antibiotic Duration in Presumed Lower Respiratory Tract Infections: A Propensity Score-Matched Cohort Across the Veterans Health Administration; Procalcitonin-Guided Antibiotic Therapy May Shorten Length of Treatment and May Improve Survival; Switch to Oral Antibiotics in Gram-Negative Bacteraemia; A Randomised, Open-Label, Clinical Trial; Risk Factors for Recurrence of Community-Onset Urinary Tract Infections Caused by Extended Spectrum Cephalosporin Resistant Enterobacterales, Editor’s Choice: IWGDF/IDSA Guidelines on the Diagnosis and Treatment of Diabetes-related Foot Infections (IWGDF/IDSA 2023); Executive Summary: Evaluation and Management of Diabetes-related Foot Infections; Efficacy and Safety of Corticosteroid Therapy for Community-Acquired Pneumonia, Impact of Doxycycline on Clostridioides difficile Infection in Patients Hospitalized with Community-Acquired Pneumonia; The Effectiveness of Fascial Closure with Antimicrobial Coated Sutures in Preventing Incisional Surgical Site Infections in Gastrointestinal Surgery; Editor’s Choice: Contemporary Management of Staphylococcus aureus Bacteremia—Controversies in Clinical Practice; Clinical Outcomes of Rifampicin Combination Therapy in Implant-Associated Infections due to Staphylococci and Streptococci; Microbial Hitchhikers Harbouring Antimicrobial-Resistance Genes in the Riverine Plastisphere; Society of Critical Care Medicine and the Infectious Diseases Society of America Guidelines for Evaluating New Fever in Adult Patients in the ICU; Safety of Early Oral Ambulatory Treatment of Adult Patients with Bloodstream Infections Discharged from the Emergency Department; Pathophysiological Responses to Bloodstream Infection in Critically Ill Transplant Recipients Compared to Non-Transplant Recipients; Fecal Microbiota Transplantation Promotes Reduction of Antimicrobial Resistance by Strain Replacement; Editor’s Choice: Impact of A Purified Microbiome Therapeutic on Abundance of Antimicrobial Resistance Genes in Patients with Recurrent Clostridioides difficile infection; Editor’s Choice: Probiotics, Prebiotics, Lactoferrin, and Combination Products for Prevention of Mortality and Morbidity in Preterm Infants; The FDA Warned Doctors Against Using Probiotics for Preterm Babies Outside of Clinical Trials; Cefoxitin Versus Carbapenems as Definitive Treatment for Extended-Spectrum Β-Lactamase-Producing Klebsiella pneumoniae bacteremia in Intensive Care Unit; Efficacy and Safety of Cefmetazole for Bacteremia Caused by Extended-Spectrum β-Lactamase–Producing Enterobacterales vs Carbapenems; Vital Signs: Missed Opportunities for Preventing Congenital Syphilis; Fall 2023 Hospital Safety Grades from The Leapfrog Group Find Improved Infection Rates Following Major Spike During COVID-19 Pandemic; Comparing Practices to Prevent Infectious Diseases Transmission Among Veterans Affairs and Non-Veterans Affairs Hospitals; Direct Gloving vs Hand Hygiene Before Donning Gloves in Adherence to Hospital Infection Control Practices; CDC Recommendations for Hepatitis C Testing Among Perinatally Exposed Infants and Children; Editor's Choice: Ecological Diversity Profiles of Non-Vaccine-Targeted HPVs After Gender-Based Community Vaccination Efforts; HICPAC Meeting, November 2-3, 2023-Masking; US Viral Respiratory Activity; Remdesivir is Associated with Reduced Mortality in COVID-19 Patients Requiring Supplemental Oxygen Including Mechanical Ventilation Across SARS-CoV-2 Variants; Effectiveness of Nirmatrelvir–Ritonavir Against the Development of Post–COVID-19 Conditions Among U.S. Veterans; Nirmatrelvir/ritonavir Use in Pregnant Women with SARS-CoV-2 Omicron Infection; WHO Guideline on Drugs for Covid-19; Plasma-Based Antigen Persistence in the Post-Acute Phase of SARS-CoV-2 Infection; Editor’s Choice: SARS-CoV-2 Virologic Rebound with Nirmatrelvir–Ritonavir Therapy

December 2023

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Rifampin Based Therapy for Patients with Staphylococcus aureus Native Vertebral Osteomyelitis: A Systematic Review and Meta-Analysis; Guidelines for the Use of Doxycycline Post-Exposure Prophylaxis for Bacterial Sexually Transmitted Infection (STI) Prevention; Wastewater-Based Surveillance Identifies Start to the Pediatric Respiratory Syncytial Virus Season in Two Cities in Ontario, Canada; The Scope of Antimicrobial Resistance in Residential Aged Care Facilities Determined Through Analysis of Escherichia coli and the Total Wastewater Resistome; Trial of Vancomycin and Cefazolin as Surgical Prophylaxis in Arthroplasty; Ceftobiprole for Treatment of Complicated Staphylococcus aureus Bacteremia; Cefepime vs Piperacillin-Tazobactam in Adults Hospitalized with Acute Infection; Understanding Vancomycin Nephrotoxicity Augmented by β-lactams: a Synthesis of Endosymbiosis, Proximal Renal Tubule Mitochondrial Metabolism, and β-lactam Chemistry; Is Short-Course Antibiotic Therapy Suitable for P Aeruginosa Bloodstream Infections in Onco-Hematology Patients with Febrile Neutropenia; The Natural History of Antibiotic-Treated Lower Limb Cellulitis: Analysis of Data Extracted from a Multicenter Clinical Trial; Decolonization in Nursing Homes to Prevent Infection and Hospitalization; Nasal Iodophor Antiseptic vs Nasal Mupirocin Antibiotic in the Setting of Chlorhexidine Bathing to Prevent Infections in Adult ICUs A Randomized Clinical Trial; Prevalence of Acinetobacter baumannii and Candida auris in Patients Receiving Mechanical Ventilation; Inhaled Amikacin to Prevent Ventilator-Associated Pneumonia; Respiratory Syncytial Virus Burden and Risk Factors for Severe Disease in Patients Presenting to the Emergency Department with Flu-Like Symptoms or Acute Respiratory Failure; Disease Severity of Respiratory Syncytial Virus Compared with COVID-19 and Influenza Among Hospitalized Adults Aged ≥60 Years —February 2022–May 2023; Characteristics and Outcomes Among Adults Aged ≥60 Years Hospitalized with Laboratory-Confirmed Respiratory Syncytial Virus —July 2022–June 2023; Mpox Vaccine; New Pentavalent Meningococcal Vaccine; FDA Authorizes Novavax’s Updated Covid Vaccine; Evaluation of Stroke Risk Following COVID-19 mRNA Bivalent Vaccines Among U.S. Adults Aged ≥ 65 Years; Use of Electronic Clinical Data to Track Incidence and Mortality for SARS-CoV-2–Associated Sepsis; Antibiotic Use Among Hospitalized Patients with COVID-19 in the United States, March 2020–June 2022; The New Normal: Delayed Peak SARS-CoV-2 Viral Loads Relative to Symptom Onset and Implications for COVID-19 Testing Programs; Preinfection Neutralizing Antibodies, Omicron BA.5 Breakthrough Infection, and Long COVID: A Propensity Score-Matched Analysis; COVID-19–Associated Hospitalizations Among U.S. Adults Aged ≥65 Years — COVID-NET, 13 States, January–August 2023; Serotonin Reduction in Post-Acute Sequelae of Viral Infection; Association Between Guillain-Barré Syndrome and COVID-19 Infection and Vaccination: A Population-Based Nested Case-Control Study; Long-Term Symptom Profiles After COVID-19 vs Other Acute Respiratory Infections: An Analysis of Data from the COVIDENCE UK Study

November 2023

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Complexity of Infectious Diseases Compared to Other Cognitive Medical Subspecialties; Infectious Diseases Consultation Associated With Reduced Mortality in Gram-Negative Bacteremia; Epidemiology, Resistance Profiles, and Outcomes of Bloodstream Infections in Community-Onset Sepsis in the United States; Promoting Appropriate Midline Catheter and PICC Placement Through Implementation of an EHR-Based Clinical Decision Support Tool: An Interrupted Time-Series Analysis; Evaluation of Hospital-Onset Bloodstream Infections Compared to Central Line–Associated Bloodstream Infections at an Acute, Tertiary Care Hospital; Are Contact Precautions “Essential” for the Prevention of Healthcare-Associated Methicillin-Resistant Staphylococcus Aureus?; Active Surveillance and Contact Precautions for Preventing Methicillin-Resistant Staphylococcus aureus Healthcare-Associated Infections During the COVID-19 Pandemic; Clinical Outcomes and Management of NAAT Positive/Toxin-Negative Clostridioides difficile Infection: A Systematic Review and Meta-Analysis; Comparison of Different Antibiotics and the Risk for Community-Associated Clostridioides difficile Infection: A Case–Control Study; Two Times Versus Four Times Daily Cephalexin Dosing for the Treatment of Uncomplicated Urinary Tract Infections in Females; Outcomes of High-Dose Oral Beta-Lactam Definitive Therapy Compared to Fluoroquinolone or Trimethoprim-Sulfamethoxazole Oral Therapy for Bacteremia Secondary to a Urinary Tract Infection; Clinician Testing and Treatment Thresholds for Management of Urinary Tract Infection; Antibiotic Prophylaxis in Infants with Grade III, IV, or V Vesicoureteral Reflux; Current Pyuria Cutoffs Promote Inappropriate Urinary Tract Infection Diagnosis in Older Women; Are Antibiotics Helpful for Older Adults with Delirium and Pyuria or Bacteriuria?; Mortality in KPC-producing Klebsiella pneumoniae Bloodstream Infections: A Changing Landscape; Higher Serologic Responses of Early Syphilis to Single-Dose Benzathine Penicillin G Plus Doxycycline Versus Single-Dose Benzathine Penicillin G Alone Among People With HIV; Treatment Failure and Adverse Events After Amoxicillin-Clavulanate vs Amoxicillin for Pediatric Acute Sinusitis; Statement Following the September 2023 FDA Meeting of the Nonprescription Drugs Advisory Committee (NDAC) to Evaluate New Data Concerning the Efficacy of Oral PE (phenylephrine); Human Papillomavirus Concordance Between Parents and Their Newborn Offspring: Results from the Finnish Family Human Papillomavirus Study; Interim Effectiveness Estimates of 2023 Southern Hemisphere Influenza Vaccines in Preventing Influenza-Associated Hospitalizations — REVELAC–i Network, March–July 2023; Prevention and Control of Seasonal Influenza with Vaccines: Recommendations of the Advisory Committee on Immunization Practices — United States, 2023–24 Influenza Season; CDC Covid-19 Hospitalizations from June 17 to September 16, 2023; Covid by the Numbers; CDC Endorses Covid-19 Boosters for Everyone Aged 6 Months and Older; KFF COVID-19 Vaccine Monitor September 2023: Partisanship Remains Key Predictor Views of COVID-19 Including Plans to Get Latest COVID-19 Vaccine; Antibody Neutralisation of Emerging SARS-CoV-2 Subvariants: EG.5.1 and XBC.1.6; Procalcitonin-Guided Antibiotic Prescription in Patients With COVID-19 A Multicenter Observational Cohort Study; IDSA Updated Covid-19 on Testing; Effect of SARS-Cov-2 Prior Infection and Mrna Vaccination on Contagiousness and Susceptibility to Infection; Nirmatrelvir/Ritonavir Use and Hospitalizations or Death in a Previously Uninfected Nonhospitalized High-Risk Population With COVID-19: A Matched Cohort Study; Nirmatrelvir or Molnupiravir Use and Severe Outcomes from Omicron Infections

October 2023

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Evaluating Antimicrobial Duration for Gram-negative Bacteremia in Patients with Neutropenia Due to Hematologic Malignancy or Hematopoietic Stem Cell Transplantation; Clinical Burden of Invasive Escherichia coli Disease Among Older Adult Patients Treated in Hospitals in the United States; Increase in the Community Circulation of Ciprofloxacin-resistant Escherichia coli Despite Reduction in Antibiotic Prescriptions; The Burden of Antimicrobial Resistance in the Americas in 2019; Reduction in Urinary Tract Infections in Patients Treated with Fecal Microbiota Transplantation for Recurrent Clostridioides difficile Infection; A Phase 2 Extension Study Evaluating the Immunogenicity, Safety, and Tolerability of 3 or 4 Doses of a Clostridioides difficile Vaccine in Healthy US Adults 65 to 85 Years of Age; Risk of Misleading Conclusions in Observational Studies of Time-to-Antibiotics and Mortality in Suspected Sepsis; The Centers for Disease Control and Prevention’s Hospital Sepsis Program Core Elements; Sepsis Program Activities in Acute Care Hospitals — National Healthcare Safety Network, United States, 2022; Diagnostic Accuracy of Hospital Antibiograms in Predicting the Risk of Antimicrobial Resistance in Enterobacteriaceae Isolates: A Nationwide Multicenter Evaluation at the Veterans Health Administration; Association Between Fluoroquinolone Use and Hospitalization with Aortic Aneurysm or Aortic Dissection; Staphylococcus Epidermidis Bloodstream Infections (SE-BSI) are a Cause of Septic Shock in ICU Patients; Healthcare Providers Consistently Overestimate the Diagnostic Probability of Ventilator-Associated Pneumonia; FDA Gives 510(k) Clearance to Respiratory Viral Panel Test for Rapid RSV, COVID-19 Detection; Infants Admitted to US Intensive Care Units for RSV Infection During the 2022 Seasonal Peak; FDA Approves First Vaccine to Protect Infants from RSV; The Plasma Metabolome of Long COVID Patients Two Years After Infection; SARS-CoV-2 — No Increased Islet Autoimmunity or Type 1 Diabetes in Teens; Impact of the COVID-19 Pandemic on Inpatient Antibiotic Use in the United States, January 2019 - July 2022; Pediatric Hospitalizations and ICU Admissions Due to COVID-19 and Pediatric Inflammatory Multisystem Syndrome Temporally Associated With SARS-CoV-2 in England; Use of Wastewater Metrics to Track COVID-19 in the US; Safety Profile and Clinical and Virological Outcomes of Nirmatrelvir-Ritonavir Treatment in Patients with Advanced Chronic Kidney Disease and Coronavirus Disease 2019 (COVID-19); Impact of SARS-CoV-2 Prevention Measures on Non-SARS-Cov-2 Hospital-Onset Respiratory Viral Infections: An Incidence Trend Analysis from 2015-2023; Assessment of Hospital-Onset SARS-CoV-2 Infection Rates and Testing Practices in the US, 2020-2022; Why Not to Pick Your Nose: Association Between Nose Picking and SARS-CoV-2 Incidence; Vaccine-Induced and Hybrid Immunity to SARS-CoV-2 After Three or Four Doses of BNT162b2 - Results from 22 Months Follow-Up of a Healthcare Workers Cohort, Israel, 2020-2022; UK Releases Recommendations for Fall COVID Boosters; COVID-19 by the Numbers; CDC/WHO Tracking New BA.2.86 Variant Of COVID-19; Risk Assessment Summary for SARS CoV-2 Sublineage BA.2.86

September 2023

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Hospital Physicians’ Stethoscopes: Bacterial Contamination After a Simple Cleaning Protocol, Vaccine Effectiveness of JYNNEOS Against Mpox Disease in the United States, Dengue Risk, Evaluating the PEN-FAST Clinical Decision-making Tool to Enhance Penicillin Allergy Delabeling, A Statewide Quality Initiative to Reduce Unnecessary Antibiotic Treatment of Asymptomatic Bacteriuria, Short-Course Therapy for Urinary Tract Infections in Children The SCOUT Randomized Clinical Trial, Characteristics, Costs, and Outcomes Associated with Central-Line-Associated Bloodstream Infection and Hospital-Onset Bacteremia and Fungemia in US Hospitals, Reliability of Admission Procalcitonin Testing for Capturing Bacteremia Across the Sepsis Spectrum: Real-World Utilization and Performance Characteristics, 65 U.S. Hospitals, 2008–2017, Real-life Assessment of BioFire Film Array Pneumonia Panel in Adults Hospitalized with Respiratory Illness, RSV Nirsevimab Antibody Injection, Seasonality in Respiratory Syncytial Virus Hospitalizations and Immunoprophylaxis, Multipathogen Respiratory Virus Testing Among Primary and Secondary School Students and Staff Members in a Large Metropolitan School District, E-11 Infections, Potential for Maternally Administered Vaccine for Infant Group B Streptococcus, The Impact of Influenza and Pneumococcal Vaccination on Antibiotic Use: An Updated Systematic Review and Meta-Analysis, Estimating the Cost of Inappropriate Antibiotic Prophylaxis Prior to Dental Procedures, Determinants of Worldwide Antibiotic Resistance Dynamics Across Drug-Bacterium Pairs, Clostridioides Difficile Infection-Associated Cause-Specific and All-Cause Mortality: A Population-Based Cohort Study, Management of Pediatric Pneumonia: A Decade After The PIDS/IDSA Guideline, Periprosthetic Joint Infection: Current Clinical Challenges, A Pathology-Based Case Series of Influenza and COVID-19-Associated Pulmonary Aspergillosis: The Proof is in the Tissue, Covid-19 Where Are We Now, Performance of Rapid Antigen Tests to Detect Symptomatic and Asymptomatic SARS-CoV-2 Infection, Transmission of SARS-CoV-2 in Free-Ranging White-Tailed Deer in the United States, Remdesivir With Severe Renal Impairment, A Common Allele of HLA is Associated with Asymptomatic SARS-CoV-2 Infection

August 2023

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Foodborne Illness Outbreaks at Retail Food Establishments — National Environmental Assessment Reporting System, 25 State, and Local Health Departments, Preliminary Incidence and Trends of Infections Caused by Pathogens Transmitted Commonly Through Food — Foodborne Diseases Active Surveillance Network, WHO Global Research Agenda for Antimicrobial Resistance in Human Health, Locally Acquired Malaria Cases Identified in the United States, ID Watch Alert: Ticks and Mosquitoes Are Carrying Diseases to More of the US, Clindamycin plus Vancomycin versus Linezolid for Treatment of Necrotizing Soft Tissue Infection, Continuous vs Intermittent Meropenem Administration in Critically Ill Patients with Sepsis, Patient-Level Meta-Analysis of Low-Dose Hydrocortisone in Adults with Septic Shock, Exeporfinium Chloride (XF-73) Nasal Gel Dosed Over 24 Hours Prior to Surgery Significantly Reduced Staphylococcus Aureus Nasal Carriage in Cardiac Surgery Patients, Effectiveness and Acceptability of Intranasal Povidone-Iodine Decolonization Among Fracture Fixation Surgery Patients to Reduce Staphylococcus Aureus Nasal Colonization, In-Class Cross-Reactivity Among Hospitalized Patients with Hypersensitivity Reactions to Fluoroquinolones, Health System Evaluation of Fluoroquinolone Hypersensitivity, Development and Validation of a Sulfa Antibiotic Allergy Clinical Decision Rule, Candida auris‒Associated Hospitalizations, Nationwide Outbreak of Candida auris Infections Driven by COVID-19 Hospitalizations, Israel, Harald zur Hausen Dies, Human Papillomavirus Vaccination, Risk of HIV Viral Rebound in the Era of Universal Treatment in a Multi-Center Sample of Persons with HIV in Primary Care, Evaluation of Oseltamivir Used to Prevent Hospitalization in Outpatients with Influenza, Influenza Southern Hemisphere, FDA Approves Pfizer’s RSV Vaccine for Older Adults, RSV Adult Vaccine Update, RSV Antibody Treatment Nirsevimab Approval, Aztreonam-avibactam (ATM-AVI), Update on Pediatric Intracranial Infections, Utility of Urine Cultures During Febrile Neutropenia Workup in Hematopoietic Stem Cell Transplantation Recipients Without Urinary Symptoms, Comparison of Medical and Mental Health Sequelae Following Hospitalization for COVID-19, Influenza, and Sepsis, FDA Panel Recommendation of COVID-19 Booster, COVID-19 By the Numbers, Trends in Laboratory-Confirmed SARS-CoV-2 Reinfections and Associated Hospitalizations and Deaths Among Adults Aged ≥18 Years — 18 U.S. Jurisdictions, Estimates of SARS-CoV-2 Seroprevalence and Incidence of Primary SARS-CoV-2 Infections Among Blood Donors, by COVID-19 Vaccination Status, Health Care-Associated Infections Among Hospitalized Patients with COVID-19, Smart Thermometer–Based Participatory Surveillance to Discern the Role of Children in Household Viral Transmission During the COVID-19 Pandemic, Molnupiravir Use and 30-Day Hospitalizations or Death in Previously Uninfected Non-Hospitalized High-Risk Population with COVID-19, Effectiveness of COVID-19 Treatment with Nirmatrelvir–Ritonavir or Molnupiravir Among U.S. Veterans: Target Trial Emulation Studies With One-Month and Six-Month Outcome, Mother to Child Transmission of SARS Cov 2 Infection in High Income Countries, Safety of COVID-19 mRNA Vaccination Among Young Children in the Vaccine Safety Datalink, Development of a Definition of Postacute Sequelae of SARS-CoV-2 Infection, Increased Hospitalizations Involving Fungal Infections During COVID-19 Pandemic

July 2023

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Clinicians of the Future-VII Editorial; Intravenous to Oral Antibiotic Switch Therapy Among Patients Hospitalized with Community-Acquired Pneumonia; Effects of Patient Beliefs Regarding the Need for Antibiotics and Prescribing Outcomes on Patient Satisfaction in Urgent-Care Settings, Sulbactam-durlobactam; Seres Therapeutics SEP-109 (Vowst); VE303, a Defined Bacterial Consortium, for Prevention of Recurrent Clostridioides difficile Infection A Randomized Clinical Trial; Fecal Microbiota Transplantation for the Treatment of Recurrent Clostridioides difficile (Clostridium difficile); Postexposure Doxycycline to Prevent Bacterial Sexually Transmitted Infections; STDs are on the Rise - New CDC Report; Epidemiology and Outcomes of Hospital-Acquired Bloodstream Infections in Intensive Care Unit Patients: the EUROBACT-2 International Cohort Study; Epidemiology, Resistance Profiles, and Outcomes of Bloodstream Infections in Community-Onset Sepsis in the United States; Incidence, Complications, and Costs of Peripheral Venous Catheter-Related Bacteraemia: A Retrospective, Single-Centre Study; Utility of Differential Time to Positivity in Diagnosing Central Line Associated Bloodstream Infections: A Systematic Review and Meta-Analysis; Efficacy and Safety of a Bivalent RSV Prefusion F Vaccine in Older Adults; Bivalent Prefusion F Vaccine in Pregnancy to Prevent RSV Illness in Infants; Reduced Respiratory Syncytial Virus Load, Symptoms, and Infections: A Human Challenge Trial of MVA-BN-RSV Vaccine; Increase in Pediatric Invasive Group A Streptococcus Infections(iGAS) — Colorado and Minnesota, October–December 2022; Worldwide Prevalence of Antibiotic-Associated Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis A Systematic Review and Meta-Analysis; European Centre for Disease Prevention and Control (ECDC) Released on COVID Vaccination; FDA and CDC Authorizes Changes to Simplify Use of Bivalent mRNA COVID-19 Vaccines; SARS-CoV-2 Neutralising Antibodies After Bivalent Versus Monovalent Booster; Durability of Bivalent Boosters Against Omicron Subvariants; Association of SARS-CoV-2 Vaccination or Infection with Bell Palsy A Systematic Review and Meta-Analysis; COVID-19 by the Numbers; Arcturus (formally, Omicron subvariant XBB.1.16) Now a VOI and XBB.1.9.1; Virological Characteristics of the SARS-CoV-2 Omicron XBB.1.16 variant; IDSA Guideline on the Treatment and Management of COVID-19 Update-Convalescent Plasma; The US FDA Gives an EUA for a New Monoclonal Antibody Treatment (vilobelimab); Optimal Duration of Systemic Corticosteroids in Coronavirus Disease 2019 Treatment: A Systematic Review and Meta-Analysis; Higher Dose Corticosteroids in Patients Admitted to Hospital With COVID-19 Who are Hypoxic but Not Requiring Ventilatory Support (RECOVERY): A Randomised, Controlled, Open-Label, Platform Trial; SARS-CoV-2 Variants and Multisystem Inflammatory Syndrome in Children; Risk of Death in Patients Hospitalized for COVID-19 vs Seasonal Influenza in Fall-Winter 2022-2023; SARS-CoV-2 During Omicron Variant Predominance Among Infants Born to People With SARS-CoV-2; Original Investigation | Pediatrics Assessment of Neurodevelopment in Infants With and Without Exposure to Asymptomatic or Mild Maternal SARS-CoV-2 Infection During Pregnancy; Maternal SARS-CoV-2, Placental Changes and Brain Injury in 2 Neonates; Sickness Presenteeism in Healthcare Workers During the Coronavirus Disease 2019 (COVID-19) Pandemic: An Observational Cohort Study; Association Between Stopping Universal SARS-CoV-2 Admission Testing and Hospital-Onset SARS-CoV-2 in England and Scotland; Universal Masking in Health Care Settings: A Pandemic Strategy Whose Time Has Come and Gone, For Now

May 2023

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Nipah Outbreak in Bangladesh; Marburg Virus Equatorial Guinea; Effect of Antibiotic Prescription Audit and Feedback on Antibiotic Prescribing in Primary Care; COVID-19 and Outpatient Antibiotic Prescriptions in the United States, Antimicrobial for 7 or 14 Days for Febrile Urinary Tract Infection in Men, A Multicenter Noninferiority Double Blind Placebo-Controlled, Randomized Clinical Trial; How Climate Change is Spreading Malaria in Africa; Rapid Range Shifts in African Anopheles Mosquitoes Over the Last Century; Real-World Use of Bezlotoxumab and Fecal Microbiota Transplantation for the Treatment of Clostridioides difficile Infection; Safety and Tolerability of SER-109 as an Investigational Microbiome Therapeutic in Adults With Recurrent Clostridioides difficile Infection: A Phase 3, Open-Label, Single-Arm Trial; Screening for Clostridioides difficile Colonization at Admission to the Hospital; The Impact of Timing of Infectious Disease Consultation for Staphylococcus Aureus Bacteremia; Health Disparities in Hemodialysis-Associated Staphylococcus Aureus Bloodstream Infections; People-Centred Framework for Addressing Antimicrobial Resistance in the Human Health Sector; Association of Proton Pump Inhibitor Use with Risk of Acquiring Drug-Resistant Enterobacterales; Increase in Extensively Drug-Resistant Shigellosis; Mpox in People with Advanced HIV Infection; CDC Panel Recommends Jynneos Vaccine for All Adults at Risk; Screening and Testing for Hepatitis B Virus Infection: CDC Recommendations; Household Transmission of Influenza A Viruses in 2021-2022; Respiratory Syncytial Virus Disease Burden in Community-Dwelling and Long-Term Care Facility Older Adults in Europe and the United States; FDA Advisors Recommend First-Ever RSV Vaccines for Adults; Physical Interventions to Interrupt or Reduce the Spread of Respiratory Viruses; First At-Home Combination Test for Flu and Covid-19; Covid-19 Impact: Three Year Anniversary; Lab Leak Most Likely Origin of Covid-19 Pandemic; Wastewater-Based Monitoring of SARS-Cov-2 at UK Airports and Its Potential Role in International Public Health Surveillance; Aircraft Wastewater Surveillance for Early Detection of SARS-Cov-2 Variants — JFK International Airport; Effect of Predeparture Testing on Postarrival SARS-Cov-2–Positive Test Results Among International Travelers — CDC Traveler-Based Genomic Surveillance Program; Viral Burden Rebound in Hospitalised Patients With COVID-19 Receiving Oral Antivirals in Hong Kong; Association of COVID-19 Vaccination with Risk for Incident Diabetes After COVID-19 Infection; Past SARS-Cov-2 Infection Protection Against Re-Infection; Rethinking Next-Generation Vaccines for Coronaviruses, Influenza Viruses, and Other Respiratory Viruses; Assessment of COVID-19 as the Underlying Cause of Death Among Children and Young People Aged 0 To 19 Years in the US; Hospital Outcomes of Community-Acquired SARS-Cov-2 Omicron Variant Infection Compared with Influenza Infection in Switzerland; Symptom and Viral Rebound in Untreated SARS-Cov-2 Infection; Impact of Vaccination on Major Adverse Cardiovascular Events in Patients With COVID-19 Infection; Effectiveness of Bivalent Mrna Booster Vaccination Against SARS-Cov-2 Omicron Infection; Bivalent Booster Effectiveness Against Severe COVID-19 2 Outcomes; Effects of Remdesivir in Patients Hospitalised With COVID-19

March 2023

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Physician 2022 Burnout Rates, Piperacillin Nephrotoxicity is Driven by Elevated Serum Trough Concentrations, Going Back in Time: Increasing Penicillin Susceptibility Among Methicillin-Susceptible Staphylococcus Aureus Osteoarticular Infections in Children, Probiotic for Pathogen-Specific Staphylococcus Aureus Decolonisation in Thailand, FDA Panel Recommends Rezafungin as New Candida Treatment, 2 Days vs. 5 Days of Postoperative Antibiotics for Complex Appendicitis, Multicentre, Noninferiority Randomised Trial, Norovirus National Trends, Outbreak of Extensively Drug-Resistant Pseudomonas Aeruginosa Associated With Artificial Tears, Comparing Complication Rates of Midline Catheter vs. Peripherally Inserted Central Catheter (PICC), High Dose Cefepime vs. Carbapenems for Bacteremia Caused by Enterobacterales With Moderate to High Risk of Clinically Significant Ampc Β-Lactamase Production, Azithromycin to Prevent Sepsis or Death in Women Planning a Vaginal Birth, Worst Avian Flu in U.S. History Is Hitting Poultry, Wild Birds, Even Bears, Bird Flu Has Begun to Spread in Mammals, Codetections of Other Respiratory Viruses Among Children Hospitalized With COVID-19, A Pragmatic Randomized Feasibility Trial of Influenza Vaccines, HHS Weekly Report (Influenza/RSV), The Influence of Rapid Influenza Diagnostic Testing on Clinician Decision-Making for Patients With Acute Respiratory Infection in Urgent Care, Sensitivity of RIDTs for Influenza, US Plans to End Public Health Emergency for Covid-19 in May, Covid-19 by the Numbers, FDA Removes Positive COVID-19 Test Requirement for Antiviral Treatments, Available Outpatient Covid-19 Treatments, Information for Persons Who are Immunocompromised Regarding Prevention and Treatment of SARS-Cov-2 Infection in the Context of Currently Circulating Omicron Sublineages, FDA Withdraws EUA for Tixagevimab/Cilgavimab, IDSA Updated Guideline for COVID-19, Early Treatment With Pegylated Interferon Lambda for Covid-19, Children and COVID: Weekly Cases, Assessment of Efficacy and Safety of Mrna COVID-19 Vaccines in Children Aged 5 to 11 Years, Adverse Events Following the BNT162b2 Mrna COVID-19 Vaccine (Pfizer-Biontech) in Aotearoa New Zealand, Novavax NVX COV2373 Triggers Neutralization of Omicron Sub Lineages, Early Estimates of Bivalent Mrna Booster Dose Vaccine Effectiveness in Preventing Symptomatic SARS-Cov-2 Infection Attributable to Omicron BA.5– And XBB/XBB.1.5–Related Sublineages Among Immunocompetent Adults — Increasing Community Access to Testing Program, COVID-19 Incidence and Mortality Among Unvaccinated And Vaccinated Persons Aged ≥12 Years by Receipt of Bivalent Booster Doses and Time Since Vaccination, Protective Effectiveness of Previous SARS-Cov-2 Infection and Hybrid Immunity Against the Omicron Variant and Severe Disease

February 2023

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Efficacy and Safety of Azithromycin vs Placebo to Treat Lower Respiratory Tract Infections Associated with Low Procalcitonin; Association of Appropriate Empirical Antimicrobial Therapy with In-Hospital Mortality in Patients with Bloodstream Infections; Antimicrobial Resistance and Mortality Following E. Coli Bacteremia; Antibiotic Use as a Risk Factor for Inflammatory Bowel Disease; Machine Learning to Stratify Methicillin-Resistant Staphylococcus Aureus Risk Among Hospitalized Patients with Community-Acquired Pneumonia; Defining Optimal Duration of Therapy for Hospitalized Patients with Complicated Urinary Tract Infections and Associated Bacteremia; Risk Factors Associated with Antimicrobial Resistance and Adverse Short-Term Health Outcomes Among Adult and Adolescent Female Outpatients with Uncomplicated UTI; Association of Pneumococcal Conjugate Vaccine Use with Hospitalized Pneumonia in Medicare Beneficiaries 65 Years or Older; Proposed HHS National Action Plan; Antibiotic Concentrations and Antibiotic Resistance in Aquatic Environments of the WHO Western Pacific and South-East Asia Regions; Uganda’s Ebola Outbreak; FDA OKs Tdap Shot in Pregnancy to Protect Newborns from Pertussis; Vaccination Coverage with Selected Vaccines and Exemption Rates Among Children in Kindergarten; Moderna Reports RSV Vaccine Cuts Risk of Respiratory Diseases in Older Adults; The Young Were Not Spared: What Death Certificates Reveal About Non-Covid Excess Deaths; Commentary: Covid-19 Year 4; Are Americans Dying from Covid-19 or with Covid-19?; WHO’s Updated Covid Guidelines; US Renews Health Emergency; NIH Updates Regarding Use of Bebtelovimab; CDC & FDA Identify Preliminary Covid Vaccine Safety Signal for Persons Aged 65 Years and Older; Combined IDSA/SHEA Statement: U.S. Must Consider Broader Measures to Mitigate COVID-19 Transmission; Covid by Numbers; Infectiousness of SARS-Cov-2 Breakthrough Infections and Reinfections During Omicron Wave; Protection Against Symptomatic Infection with Delta and Omicron BA.1 and BA.2 SARS-Cov-2 Variants After Previous Infection and Vaccination in Adolescents; Enhanced Transmissibility of XBB.1.5 is Contributed by Both Strong ACE2 Binding and Antibody Evasion; Neutralisation Sensitivity of the SARS-Cov-2 XBB.1 Lineage; COVID-19 Convalescent Plasma for Treatment of Immunocompromised Patients; Effectiveness of Bivalent mRNA Vaccine in Preventing Severe Covid Outcomes; Impaired CD4+ T Cell Response in Older Adults is Associated with Reduced Immunogenicity and Reactogenicity of mRNA Vaccination; Outcomes Among Mechanically Ventilated Patients with Severe Pneumonia and Acute Hypoxemic Respiratory Failure from SARS-Cov-2 and Other Etiologies; Long Covid Outcomes at One Year After Mild SARS-Cov-2 Infection; Long COVID: Major Findings, Mechanisms and Recommendations

January 23, 2023

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General Infectious Diseases: Shortage of Infectious Disease Physicians, Impact of Rapid Molecular Test for Klebsiella pneumoniae Carbapenemase and Ceftazidime-Avibactam Use on Outcomes After Bacteremia Caused by Carbapenem–Resistant Enterobacterales, Case-Control Study Evaluating Unnecessary Use of Intravenous Broad-Spectrum Antibiotics in Presumed Sepsis and Septic-Shock Patients, Association of Follow-Up Blood Cultures with Mortality in Patients with Gram-Negative Bloodstream Infections a Systematic Review and Meta-Analysis, Increase in Pediatric Invasive Group A Streptococcal Infections, Association of Adverse Events with Antibiotic Treatment for Urinary Tract Infection; Mpox: Surveillance, Case Investigation and Contact Tracing for Monkeypox: Interim Guidance, Mpox by Numbers, Clinical Features and Management of Individuals Admitted Hospital with Monkeypox and Associated Complications Across the UK; Respiratory Viruses (Not SARS-Cov-2): Prevalence of SARS-Cov-2 and Influenza Coinfection and Clinical Characteristics Among Children and Adolescent Aged, Influenza Vaccine Effectiveness Against Influenza A(H3N2)- Related Illness in United States During 2021–2022 Influenza Season, Respiratory Viruses by Numbers; COVID-19: Covid-19 Risk Continuum, US Offers Free At-Home Tests Again, US to Require Negative Tests for Travelers Coming from China, IDSA Update on Antigen Testing, Covid-19 by Numbers, Association of Time to Surgery After Infection with Risk of Postoperative Cardiovascular Morbidity, Asymptomatic Screening for Severe Acute Respiratory Coronavirus Virus 2 (SARS-Cov-2) as an Infection Prevention Measure in Healthcare Facilities: Challenges and Considerations, SARS-Cov-2 Infection History and Antibody Response to Three Mrna Vaccine, Molnupiravir Plus Usual Care Versus Usual Care Alone as Early Treatment for Adults with COVID at Increased Risk of Adverse Outcomes (PANORAMIC): An Open-Label, Platform Adaptive Randomised Controlled Trial, VV116 Versus Nirmatrelvir–Ritonavir for Oral Treatment, High Titers of Infectious SARS-Cov-2 in COVID Corpses, Postmortem Stability of SARS-Cov-2 in Nasopharyngeal Mucosa, Infectivity of Deceased COVID Patients, SARS-Cov-2 Infection and Persistence in Human Body and Brain at Autopsy, Council of State and Territorial Epidemiologists/CDC Surveillance Case Definition for Multisystem Inflammatory Syndrome in Children Associated with SARS-Cov-2 Infection, Alarming Antibody Evasion Properties of Rising SARS-Cov-2 BQ and XBB Subvariants, Early Estimates of Bivalent Mrna Vaccine Effectiveness in Preventing COVID – Associated Emergency Department or Urgent Care Encounters and Hospitalizations Among Immunocompetent Adults, Early Estimates of Bivalent Mrna Vaccine Effectiveness in Preventing COVID – Associated Hospitalization Among Immunocompetent Adults Aged ≥65 Years, Predictors of Severe Acute Respiratory Syndrome Coronavirus 2 Infection Following High-Risk Exposure, Impact of SARS-Cov-2 Variants on Inpatient Clinical Outcome, Outcomes and Adverse Effects of Baricitinib Versus Tocilizumab in the Management of Severe COVID

January 1, 2023

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General Infectious Diseases: Anti-Anaerobic Antibiotics Increase Risk of Adverse Clinical Outcomes In Critically Ill Patients, Effect of Selective Decontamination of Digestive Tract on Hospital Mortality in Critically Ill Patients Receiving Mechanical Ventilation, Association Between Selective Decontamination of Digestive Tract and In-Hospital Mortality in Intensive Care Unit Patients Receiving Mechanical Ventilation, FDA OKs First Fecal Transplant Therapy for Recurrent C Difficile, Efficacy and Safety of RBX2660 in PUNCH CD3, a Phase III, Randomized, Double Blind, Placebo Controlled Trial, Progress Toward Regional Measles Elimination, Respiratory Viruses: RSV by Numbers, Influenza by Numbers, VE of Influenza Vaccination of Pregnant for Prevention of Maternal and Early Infant Hospitalizations in South Africa, A Multivalent Nucleoside-Modified Mrna Vaccine Against All Known Influenza Virus Subtypes, Mpox: Mpox by Numbers, Single and 2-Dose Vaccinations with Modified Vaccinia Ankara-Bavarian Nordic® Induce Durable B Cell Memory Responses, Reduced Risk for Mpox After Receipt of 1 or 2 Doses of JYNNEOS Vaccine Compared with Risk of Unvaccinated, COVID-19: FDA Authorizes Updated Covid Vaccines for Children as Young As 6 Months, Here We Go Again and Covid by Numbers, Bebtelovimab Update, Association of COVID with Diabetes: A Systematic Review and Meta Analysis, Free Fatty Acid–Binding Pocket is a Conserved Hallmark in Pathogenic Β-Coronavirus Spike Proteins from SARS-Cov to Omicron, Shifting Mortality Dynamics in US During Covid Pandemic as Measured by Years of Life Lost, Medical Masks vs N95 Respirators for Preventing Covid Among Health Care Workers, Association of Initial SARS-Cov-2 Test Positivity with Patient-Reported Well-Being 3 Months After Symptomatic Illness, VE of Mrna-1273, BNT162b2, and BBIBP-Corv Vaccines Against Infection and Mortality in Children in Argentina, SARS-Cov-2 Viral Load and Shedding Kinetics, Low Neutralization of SARS-Cov-2 Omicron BA.2.75.2, BQ.1.1, and XBB.1 by Parental Mrna Vaccine or a BA.5-Bivalent Booster, Efficacy of Antiviral Agents Against Omicron Subvariants BQ.1.1 and XBB, Twice-Daily Oral Zinc in Treatment of Patients with Coronavirus Disease 2019: A Randomized Double-Blind Controlled Trial

December 12, 2022

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General Infectious Diseases: Early Mobilization Mechanical Ventilation in ICU, AR in EU, Increase in Bsis with CRAB 2020 and 2021 in EU, Infection Prevention Staffing Levels and Hais, Global Mortality Associated with 33 Bacterial Pathogens in 2019, 5-Ethyl-2-Deoxyuridine K Pneumoniae Intracellular Killing, Clinical Impact of Ceftriaxone Resistance in E Coli BSI, Evaluation of Opt-Out Protocol for De-Escalation in Sepsis, Discontinuing MRSA And VRE Contact Precautions; Respiratory Viruses: Association Between Influenza Vaccination and Risk of Stroke, Influenza Vaccine to Reduce Adverse Vascular Events in Patients with Heart Failure, Influenza by the Numbers, Other Respiratory Viruses by the Numbers; Monkeypox: WHO Renames Monkeypox, Monkeypox by Numbers, Mutations in Virus Replication, Tecovirimat Resistance, Human Monkeypox in Women and Non-Binary Individuals, Effectiveness of One Dose of MVA-BN Smallpox Vaccine Against Monkeypox; COVID-19: Moderna Bivalent Booster, Pfizer Bivariant Against BQ.1.1, Covid by Numbers, Covid No Longer Mainly a Pandemic of the Unvaccinated, Changes in Population Immunity Against Infection and Severe Disease from Omicron Variants, Effectiveness of Bivalent Mrna Vaccines in Preventing Symptomatic Infection, Paxlovid Associated with Decreased Hospitalization Rate Among Adults, Prevalence of Contraindications to Nirmatrelvir-Ritonavir, Diagnostic Accuracy of Rapid Antigen Self-Tests in Asymptomatic Individuals, Covid and Excess All-Cause Mortality in the US and 20 Comparison Countries, Omicron Sublineage BQ.1.1 Resistance to Monoclonal Antibodies, Saliva Antibody-Fingerprint of Reactivated Viruses After Mild/Asymptomatic Covid, Vaccine Effectiveness Against Reinfection

November 28, 2022

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Safety and Efficacy of a Monoclonal Antibody Against Malaria in Mali, Routine Sterile Glove and Instrument Change at the Time of Abdominal Wound Closure to Prevent Surgical Site Infection, Comparative Safety and Health Care Expenditures Following Inappropriate Versus Appropriate OP Antibiotic URI, Viral Shedding 1 Year Following First-Episode Genital HSV-1 Infection, 2021 HAI Progress Report; Monkeypox: HHA Renews Public Health Emergency, Monkeypox by Numbers, Transmission Dynamics of MPXV in UK, Epidemiol and Clinical Features Children and Adolescents with MPXV, Global MPXV Hospitalization Rates; Influenza and RSV, Influenza Rates in US, RSV Rates in US; COVID-19: The Rise of BQ, Covid by Numbers, HHS Extend Health Emergency, Pfizer Bivalent Vaccine Study, EUA Anakinra, AAP Report, Hospitalizations Among US Infants, Variants to Watch, Safety Monitoring of Bivalent Vaccine Booster Persons ≥12 Years, Gut Microbiome Dysbiosis in Antibiotic Treated Patients with Bsis, Health Impairment in Children and Adolescents After Hospitalization with MIS-C, Comparative Risk Myocarditis/Pericarditis After Second Dose of Pfizer and Moderna, Protection Against Omicron from Vaccination and Previous Infection in Prison System, Fostamatinib for Treatment of Hospitalized Adults, VL Dynamics Delta and Omicron Variants Following Vaccination and Previous Infection, Nirmatrelvir and Risk of Post-Acute Sequelae, Translation Feasibility and Efficacy of Nasal Photodynamic Disinfection of SARS-Cov-2, Lifting Universal Masking in Schools, Acute and Postacute Sequelae Associated with Reinfection

November 14, 2022

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Diagnostic Accuracy of Bacterial and Viral Biomarker Point-of-Care Test in Outpatient Setting, Effectiveness of Ultraviolet-C Disinfection on Hospital-Onset Gram-Negative Rod Bloodstream Infection, Clinical Impact of Ceftriaxone Resistance in Escherichia Coli Bloodstream Infections, Changes in Burnout and Satisfaction with Work-Life Integration in Physicians During the First 2 Years of the COVID-19 Pandemic, Ebola: Uganda as Outbreak Grows to 100 Confirmed Cases; Fungal Report: WHO Fungal Priority Pathogens List to Guide Research, Development, and Public Health Action; Evolution of the Human Pathogenic Lifestyle in Fungi, Increased Deaths from Fungal Infections During the COVID-19 Pandemic, Pan-Cancer Mycobiome Analysis Reveals Fungal Involvement in Gastrointestinal and Lung Tumors; Respiratory Viruses: Tripledemic?, Vital Signs: Influenza Hospitalizations and Vaccination Coverage by Race and Ethnicity, Influenza and COVID-19 Vaccination Coverage Among Health Care Personnel; Monkeypox: Ocular Monkeypox, Infection Resulting from an Occupational Needlestick, Severe Monkeypox in Hospitalized Patients, Monkeypox by Numbers; COVID-19: FDA Authorizes Novavax as Booster for Adults, ACIP Support Adding Vaccines to Regular Immunizations, Variants BQ.1 and BQ.1.1, NIH COVID-19 Treatment Guidelines Panel’s Statement on Omicron Subvariants and Anti-SARS-CoV-2 Monoclonal Antibodies, Covid by Numbers, GAO Report: Maternal Health, Multicenter Comparison of Prevalence and Predictors of Antimicrobial Resistance in Hospitalized Patients Before and During Pandemic, Estimated Protection of Prior Infection Against Reinfection with the Omicron Variant Among Messenger RNA, Adverse Childhood Experiences During and Associations with Poor Mental Health and Suicidal Behaviors Among High School Students, Clinical Effectiveness and Safety of Remdesivir in Hemodialysis Patients with Covid, Association of mRNA Vaccination with Clinical and Virologic Features of Covid Among US Essential and Frontline Workers, Prevalence of Positive Rapid Antigen Tests After 7-Day Isolation Following Infection in College Athletes During Omicron Variant Predominance, Neutralization Escape by Omicron Subvariant BA.4.6, Effect of Ivermectin vs Placebo on Time to Sustained Recovery in Outpatients with Mild to Moderate Covid, Antibody Responses to Omicron BA.4/BA.5 Bivalent mRNA Vaccine Booster, Immunogenicity of the BA.5 Bivalent mRNA Vaccine Boosters, Recurrence of Symptoms Following a 2-Day Symptom Free Period in Patients with Covid

October 31, 2022

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General Infectious Diseases: FDA Pertussis Vaccine Approval, Outbreak Ebola Virus Central Uganda, Transmission of Carbapenem KP in US Hospitals, Correlation of Pyuria and Bacteriuria, Administration of a β-lactam Prior to Vancomycin; Influenza: 2022 National Survey: Attitudes about Influenza and Pneumococcal Disease and Impacts of Covid, US Flu Activity; Monkeypox: FDA EUA for New Monkeypox Test, Risk of Monkeypox Transmission to HCP, Epidemiological and Clinical Characteristics of Patients with Monkeypox, COVID: APIC Response to Lifting Universal Masking, Variant Updates, Covid by Numbers, XBB Variant, Evusheld Against BA.4.6, Commonwealth Analysis on Boosters, Preliminary on Pfizer Bivalent Vaccine, Novavax Booster, Pediatric Antibody Prevalence, FDA Approval Bivalent Boosters Ages 5-11; Clinical, Virologic, and Immunologic Evaluation Rebound Following Nirmatrelvir/Ritonavir, Diagnostic Accuracy of Rapid Antigen Tests with Unsupervised Self-Sampling, Clinical and Genetic Risk Factors VTE in Ambulatory Patients, Peripartum Outcomes Associated with Vaccination During Pregnancy, Impact of SARS-CoV-2 Vaccination and Boosters on Symptom Severity, Association Between Vaccination Status and Mortality Among Intubated Patients, Effectiveness and Durability of Pfizer Vaccine Against Hospitalization and ED Admissions, Severe Outcomes after Full Vaccination and Initial Booster, New Symptoms and Prevalence of Postacute Covid-19 Among Nonhospitalized Survivors, Molnupiravir Versus Usual Care in Early Treatment

October 17, 2022

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Mupirocin Susceptibility of Staphylococci, Efficacy of Different Preoperative Skin Antiseptics on Incidence of Surgical Site Infections, Norovirus Outbreaks Reported Through NoroSTAT, Increase in Acute Respiratory Illnesses Among Children and Adolescents Associated with Rhinoviruses and Enteroviruses, Including Enterovirus D68, FDA Votes in Favor of Fecal Transplant Therapy RBX2660 for Recurrent C. difficile Infection, Influenza Vaccines 2022-3, “Twindemic” Risk, Repeated Influenza Vaccination Effectiveness, Monkeypox: Severe Manifestations of MPXV Among People Who are Immunocompromised, Neurologic Complications of Smallpox and Monkeypox A, Effectiveness of a Single-Dose Modified Vaccinia Ankara in Human Monkeypox, Monkeypox by the Numbers, COVID-19: BA.5.2.1.7 (BF.7 for short), CDC Revises Masking Guidance for Healthcare Facilities, CDC Revised Its "Up to Date" Vaccination, COVID by the Numbers, Emotional Exhaustion Among US HCWs Before and During Pandemic, Long-Term Neurologic Outcomes of COVID-19, Association of SARS-CoV-2 Infection With New-Onset Type 1 DM Among Pediatric Patients, Odds of Hospitalization After 3 vs 2 Doses of mRNA Vaccine by Time Since Booster, Protection Against BA.2 Reinfection Conferred by Primary Omicron BA.1 or Pre-Omicron SARS-CoV-2 Infection Among HCWs With and Without mRNA Vaccination, Longitudinal Eval of AB Persistence in Mother-Infant Dyads Following SARS-CoV-2 Infection in Pregnancy, MRSA Bacteremia During Pandemic

October 2, 2022

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Risk Factors and Clinical Outcomes Associated with Blood Culture Contamination, Evaluation of Hospital Blood Culture Utilization Rates to Identify Opportunities for Diagnostic Stewardship, Impact of Antimicrobial Stewardship Program on Hospital Acquired Candidemia, Association Between Time to Appropriate Antimicrobial Treatment and 30-day Mortality in Patients with Bloodstream Infections, Polio Declared State of Emergency for New York, Trends in Parents’ Confidence in Childhood Vaccines During Pandemic, Severe Respiratory Illnesses Associated with Rhinoviruses and/or Enteroviruses Including EV-D68 – Multistate, 2022; Monkeypox: Presenting as Proctitis in Men Who Have Sex with Men, Single and 2-dose Vaccinations with MVA-BN® Induce Durable B Cell Memory Responses in Healthy Volunteers Comparable to Older Generation Replicating Smallpox Vaccines, Two Cases of Monkeypox-Associated Encephalomyelitis, LA County Man Died from Monkeypox, Guidance for Tecovirimat Use Under Expanded Access Investigational New Drug Protocol during 2022 U.S. Outbreak, FDA Warns Monkeypox Virus May Develop Resistance to Tecovirimat, Case Trends in US, HIV and Sexually Transmitted Infections Among Persons With Monkeypox; COVID: Updates, The Lancet Commission on Lessons for Future Pandemic, Association Between BNT162b2 Vaccination and Reported Incidence of Post-COVID Symptoms: Cross-Sectional Study 2020-21, Israel, Mortality Risk Among Patients Hospitalized Primarily for COVID During Omicron and Delta Variant Pandemic Periods, Hospitalizations Among Vaccinated and Unvaccinated Adults 18 Years or Older in 13 US States, Resistance of SARS-Cov-2 Omicron Subvariant BA.4.6 to Antibody Neutralization, Effect of Test-and-Treat Approach to Vitamin D Supplementation on Risk of All Cause Acute Respiratory Tract Infection and COVID: Phase 3 Randomised Controlled Trial (CORONAVIT), Detection of Higher Cycle Threshold Values in Culturable SARS-Cov-2 Omicron BA.1 Sublineage Compared With Pre-Omicron Variant Specimens, Antibody from Single Human VH-Rearranging Mouse Neutralizes All SARS-Cov-2 Variants Through BA.5 by Inhibiting Membrane Fusion, Vaccines in Infants, Children, and Adolescents, Effectiveness and Durability of BNT162b2 Vaccine Against Omicron Sublineages in South Africa

September 18, 2022

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Ultra-Short-Course Antibiotics for Suspected Pneumonia With Preserved Oxygenation, Short-Course Antibiotic Therapy for Hospitalised Patients with Early Clinical Response in Community-Acquired Pneumonia: A Multicentre Cohort Study, Efficacy of Doxycycline for Mild-to-Moderate Community Acquired Pneumonia in Adults: A Systematic Review and Meta-analysis of Randomized Controlled Trials, Two-Day vs Seven-Day Course of Levofloxacin in Acute COPD Exacerbation: A Randomized Controlled Trial, CDCRreorganization; Monkeypox: FDA Alert Regarding Fecal Microbiota Transplants, Monkeypox by Numbers, High-Contact Object and Surface Contamination in a Household of Persons with Monkeypox Virus Infection — Utah, June 2022, Environmental Persistence of Monkeypox Virus on Surfaces in Household of Person with Travel-Associated Infection, Dallas, TX, Clinical Features and Novel Presentations of Human Monkeypox - London Centre; Covid-19: FDA Authorizes Emergency Use for Novavax for Ages 12-17; Moderna Sues Pfizer and BioNTech; Pfizer and Moderna Files for Emergency Use of BA.4/BA.5 Omicron Booster, Omicron Subvariant BA.2.75, Covid Hospitalization by Age, Covid by Numbers, Test-to-Stay (TTS) After SARS-CoV-2 Exposure: A Mitigation Strategy for Optionally Masked K-12 Schools, Durability of Heterologous and Homologous Vaccine Boosts, Randomized Trial of Metformin, Ivermectin, and Fluvoxamine, Oral Nirmatrelvir and Ritonavir in Non-Hospitalized Vaccinated Patients, Nirmatrelvir Use and Severe Outcomes During Omicron Surge, Real-World Effectiveness of Early Molnupiravir or Nirmatrelvir– Ritonavir in Hospitalised Patients Without Supplemental Oxygen, Requirement on Admission During Hong Kong’s Omicron BA.2 Wave: A Retrospective Cohort Study, Safety Monitoring of Pfizer-BioNTech Vaccine Booster Among Children Aged 5–11 Years — United States, May 17–July 31, 2022, Incubation Period Caused by Unique SARS-CoV-2 Strains A Systematic Review and Meta-Analysis, Risk for Myocardial Infarction, Stroke, and Pulmonary Embolism Following Vaccines in Adults Younger Than 75 Years in France

August 29, 2022

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Faecal microbiota transplantation reduces amounts of antibiotic resistance genes in patients with multidrug-resistant organisms; Multicenter Cohort Study of Ceftaroline versus Daptomycin for Treatment of Methicillin-Resistant Staphylococcus aureus Bloodstream Infection; US Considers Lengthening Gap Between First 2 COVID Shots to 8 Weeks; COVID-19 vaccine for kids under 5 delayed; FDA Authorizes New MCA, Bebtelovimab for Treatment of COVID-19; DSA Convalescent Plasma Guideline Update January 31, 2022; Vaccines Elicit Highly Conserved Cellular Immunity to SARS-CoV-2 Omicron; Gut microbiota dynamics in a prospective cohort of patients with post-acute COVID-19 syndrome; Association of SARS-CoV-2 Infection With Serious Maternal Morbidity and Mortality From Obstetric Complications; Characteristics, Outcomes, and Severity Risk Factors Associated With SARS- CoV-2 Infection Among Children in the US National COVID Cohort Collaborative; Durability of Anti-Spike Antibodies in Infants After Maternal COVID-19 Vaccination or Natural Infection; High Rates of Rapid Antigen Test Positivity After 5 days of Isolation for COVID-19; Initial analysis of viral dynamics and circulating viral variants during the mRNA- 1273 Phase 3 COVE trial; Protection against the Omicron Variant from Previous SARS-CoV-2 Infection; Waning 2-Dose and 3-Dose Effectiveness of mRNA Vaccines Against COVID-19– Associated Emergency Department and Urgent Care Encounters and Hospitalizations Among Adults During Periods of Delta and Omicron Variant Predominance — VISION Network, 10 States, August 2021–January 2022

February 14 2022

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